Multiple myeloma is a cancer of plasma cells. With talquetamab, only about half the patients make it to only a little more than a year before they relapse. "Hydrate, hydrate, hydrate," she said. It is graphic, but it prepared patients for what to expect.. "Talquetamab induced a substantial response among patients with heavily pretreated, relapsed, or refractory multiple myeloma, the second-most-common blood cancer. Dr. Chari explained: A complete response isnt actually a cure but its basically getting it down to a level where its undetectable. Through patient education tactics, oncology nurses can help patients with multiple myeloma mitigate the oral and dermatologic toxicities associated with talquetamab. Talquetamab is an IgG4 Fc-containing BsAb targeting G- protein-coupled receptor family C group 5 member D . Unable to load your collection due to an error, Unable to load your delegates due to an error. A total of 5 patients experienced dose interruptions because of a TEAE. These arent people with many options remaining, so in that setting 50% improvement is fantastic, he added. The younger patient doesnt, but Bluebird still plans to screen for patients with the alpha thalassemia trait in the future and exclude them from its ongoing studies. Drugs targeting GPRC5D, for instance, could offer an alternative to BCMA-binding treatments. Krina Patel, MD, MSc, discusses research and initiatives that may help to mitigate disparities in patients with multiple myeloma including factors such as gender, race, and ethnicity. This was for talquetamab, which again targets this specific anchor. A low blood cell count, called cytopenia, was among the most common adverse events . There are currently three FDA-approved bispecfiic antibody therapies on the market (primarily targeting cancers), and more than 100 prospective antibodies in clinical trials (aimed at everything from Alzheimer's to diabetes). The median duration of response was 10.2 months and 7.8 months, respectively. The abnormal plasma cells are made from stem cells in the bone marrow. Talquetamab (JNJ-64407564) is a bispecific IgG4 antibody that redirects T-cell killing to multiple myeloma cells by binding to the novel target, GPRC5D, and CD3. Kathleen Gander DNP, APRN, CNS; and Sarah Middlekauff, MSN, RN, OCN, relay their experiences in implementing a hepatic artery infusion pump educational intervention for oncology nurses. The cases occurred in one adult and one younger study participant. For example, skin and ear problems, which can sometimes affect patients a little bit differently, but can also be a quality-of-life issue. Bluebird believes lovo-cel may exacerbate the problems linked to alpha thalassemia trait. Talquetamab. Vyvgart, also known as efgartigimod, could help when other therapies dont work, study results presented Sunday suggest. These cells, made in the bone marrow, are a vital part of . Accessibility These trials could give people with myeloma the chance to live longer by keeping their cancer at bay.. Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. . You can use your HealthTree data to see if you qualify to join a talquetamab trial. While Phase 1 trials are for the purpose of determining safety and dosage, they do yield results on side effects and efficacy as well. SGO 2023 Annual Meeting on Womens Cancer, FDA Approves Polatuzumab Vedotin-piiq Plus R-CHP for Previously Untreated DLBCL Not Otherwise Specified and High-Grade B-Cell Lymphoma, Exercise and Wellness Programs May Enhance Well-Being and Reduce Health-Care Costs in Patients With Breast Cancer, Does Surveillance Mammography Benefit Geriatric Patients With Breast Cancer, Intraoperative vs Postoperative Lymph Node Pathology Evaluation in Patients With Breast Cancer Undergoing Mastectomy, Subcutaneous vs Intravenous Rituximab in First-Line Treatment of LowTumor Burden Follicular Lymphoma. Although all oral symptoms were categorized as grade 1 or 2, they still had a significant effect on quality of life and treatment continuation; dysgeusia was responsible for 3 cases of dose interruptions, 1 case of dose reduction, and 1 treatment discontinuation; dysphagia was the catalyst for 3 cases of treatment interruptions. The results of the phase 1 trial appeared in the New England Journal of Medicine, and the phase 2 trial results were presented at the annual meeting of the American Society of Hematology. Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life The appearance of Johnson & Johnson's talquetamab in this year's Ash press programme will highlight GPRC5D blockade as an important new mechanism in treating multiple myeloma. Talquetamab appears to have a have favorable risk/benefit profile in RRMM with durable responses and manageable toxicities. CRS and cytopenia were primarily observed in early cycles and were reversable. Thus, combination therapies may both enhance activity and offer a favorable side-effect profile. In total 70% of patients experienced Cytokine Release Syndrome (CRS) but all events were minor. An official website of the United States government. A medrol dose (Pak) may be used for more severe cases. Talquetamab for Multiple Myeloma Talquetamab, a bifunctional antibody, directs activated T cells to tumor. It was pretty gross. The gist was that the temporary side effect was nothing if the drug works! Beth Faiman Discusses Recent Changes in Multiple Myeloma Treatment Landscape. Side Effects: Some Common, Some Unusual. This drug entry is a stub and has not been fully annotated. Side Effects I've Experienced with Talquetamab - myelomablog This year, among the several bi-specifics on the ASH agenda, Talquetamab still peaks my interest. Anemia, in this context, can be worrisome as a potential sign of emerging blood cancer. Nearly 60% had a very good partial response, meaning that their cancer was substantially reduced. Educated Patient Multiple Myeloma Summit BiTE and Future Myeloma More Than 70% of Heavily Pretreated Patients Taking Talquetamab for Experimental cancer therapy shows success in | EurekAlert! Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Other than some minor fatigue and some of the normal side effects of being 66, Im feeling great! His interests focus on psychedelic science, new media, and science oddities. In addition, several other studies are underway to assess the use of talquetamab in combination with other existing and investigational multiple myeloma therapies, which could allow patients to have similar or improved benefits, potentially in earlier stages of treatment. (Its also found on hairfollicle cells but dont worry youre not going to lose your hair again.) After initial priming, patients received either weekly or biweekly dosing throughout the study duration. When patients are having taste changes, and their wife is in tears saying I want him to eat, he wont eat, what do I do? Thats where we really can come in and help., Aronson is a clinical nurse practitioner specializing in bone marrow transplant and immune effector cell therapies at Mount Sinai Hospital. Of these, dysgeusia, dry mouth, and dysphagia were the most experienced symptoms. Side effects with talquetamab were meanwhile relatively frequent, but typically mild. At least he plans to, but we have zero CAR-T capacity and no idea when the situation . We've talked about this, but just to . Another anti-CD38/CD3 BiTE . ASH 2021: Update on Talquetamab - HealthTree for Myeloma The Talquetamab / Daratumumab trial. Nurses Exchange Best Strategies in Improving Delivery of Hepatic Artery Infusion Pump Education. Taltz | European Medicines Agency . making it an attractive therapeutic target. Bluebird attributed both to underlying genetics specifically, a condition known as alpha thalassemia trait that is associated with anemia. Between the Lines Podcast: Updates in Use of Proteasome Inhibitors for Relapsed/Refractory Multiple Myeloma. Type. Novel Experimental Drugs for Treatment of Multiple Myeloma Epcoritamab Shows a Manageable Safety and Robust Antitumour Dr. Chari explained: Myeloma response means [] theres a 50% reduction in the myeloma level, so if its less than 50% it is not considered a response and when you submit to the [Food and Drug Administration], and when they look at regulatory approval, its 50% or higher. Bispecific Antibody Platform: Early Data in Relapsed and Refractory New medicine for multiple myeloma patients with limited treatment a condition causing fever, vomiting, shortness of breath, headache and low blood . doi: 10.1016/j.bulcan.2021.10.003. Talquetamab: Uses, Interactions, Mechanism of Action - DrugBank Off-the-shelf immunotherapy could offer new hope for patients with hard The researchers said very few patients (5-6%) stopped talquetamab treatment because of side effects. The primary end points - the frequency and type of dose-limiting toxic effects (study part 1 only), adverse events, and laboratory abnormalities - were assessed in order to select the recommended doses for a phase 2 study. Should it win an OK, talquetamab would join a cell therapy and another, recently cleared bispecific antibody in J&Js portfolio of multiple myeloma treatments. The study participants had all been previously treated with at least three different therapies without achieving lasting remission, suggesting talquetamab could offer new hope for patients with hard-to-treat multiple myeloma. We've been so busy adding drugs to the arsenal that [were] catching up to figure out the right sequences and unanswered questions.. Talquetamab is an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody that targets GPRC5D. The same side effects that I mentioned are cytokine release syndrome. One of the things that I think is very telling with efgartigimod is, no matter what subgroup we looked at, it showed a benefit over placebo, said Broome. with Ongoing trials are assessing the optimal phase 2 dose, as well as assessing the agents efficacy in combination with approved and investigational therapy. Track your myeloma and find treatment options, Journal your myeloma story in video, audio and writing, Learn from 150+ myeloma experts in video lessons, Find a free personal coach to help navigate your myeloma, Join our new social media app for myeloma patients, Tackle challenges and crush your fitness goals together, Stay up-to-date with thousands of myeloma news articles, Listen to one-on-one interviews with experts on clinical trials, Attend in-person meetings with myeloma experts, Join community groups with other patients and caregivers, Answer survey questions to advance myeloma research, Find answers to commonly asked questions when navigating HealthTree services. Apr 28, 2023 11:39am. 2021 Oct;108(10S):S205-S212. News release. (If you just need to know, that stands for G Protein-coupled Receptor class C Group 5 member D.). Nurses should encourage patients to incorporate thin liquids into their diet. Talquetamab (JNJ-64407564) Several studies are exploring bispecific mAbs with antigen target different from BCMA. Presented at: European Hematology Association Congress 2022; June 9-12, 2022; Vienna, Austria. Now, talquetamab, or talq for short, is a bi-specific antibody against a target called GPRC5D. Talquetamab for RRMM Granted FDA Breakthrough Therapy Designation Xerostomia . But a new kind of therapy, a bispecific antibody called Talquetamab, has been showing pro . All participants had received at least three prior treatments, including other types of drugs. Talquetamab is a first-in-class, off-the-shelf (ready to use), investigational bispecific T-cell engager antibody targeting both GPRC5D, a novel multiple myeloma target, and CD3, a primary . Victoria R. Crowder, BSN, RN, and co-investigators, highlight existing gaps in the understanding of malnutrition risks facing patients with acute myeloid leukemia and myelodysplastic syndromes. The .gov means its official. Bispecific T cell engagers: an emerging therapy for management of The technology has been in development for decades but it has only been in the last few years that bispecific antibodies have finally reached clinical uses. The primary objectives were to identify the recommended phase 2 doses (RP2Ds) (part 1) and assess talquetamab's safety and tolerability at the RP2Ds (part 2). Hitting GPRC5D made its first splash as part of a preclinical Juno/Celgene Car-T therapy back at Ash 2018, and though it took a long time for this asset to enter the . DREAMM-5 study: investigating the synergetic effects of belantamab mafodotin plus inducible T-cell co-stimulator agonist (aICOS) combination therapy in patients with relapsed/refractory multiple myeloma [abstract]. Oyster mushrooms for cancer: Do they help? ORR at RP2D (405 g/kg SC) was 69% in 19 pts treated at this dose. If you . June 29, 2022. The blood tests which measured my myeloma (M spike, IGG, free light chains) all stayed pretty stable. In an early-phase trial, nearly three-quarters of patients who received talquetamaba first-in-class, off-the-shelf, T-cellredirecting bispecific antibody targeting both the GPRC5D and CD3 receptorsfor relapsed or refractory multiple myeloma saw a significant reduction in cancer burden within a few months. Children and Cancer . runny or stuffy nose. More than 30% of patients in both groups had a complete response or better, and nearly 60% had a very good partial response or better. The results suggest that talquetamab could give hope to patients with refractory myeloma. Management of Relapsed-Refractory Multiple Myeloma in the Era of Advanced Therapies: Evidence-Based Recommendations for Routine Clinical Practice. Taste changes were very common, Aronson said. As part of CancerNetworks Face-Off video series, Sikander Ailawadhi, MD, professor of medicine in the Division of Hematology/Oncology at the Mayo Clinic, Jacksonville, Florida, discussed results from the phase 1/2 MonumenTAL-1 trial (NCT04634552), designed to investigate talquetamab in heavily pretreated patients with relapsed/refractory multiple myeloma. Heres the joy part. Talquetamab is a CPRC5DxCD3 . This is a list of most of the side effects I've had since I started talquetamab. 5 months after I stopped, I recovered my sense of taste. Dose delays may also be an effective method of mitigating oral and dermatologic therapies, she . And this will us the idea that, for example, if you've had a BCMA-directed CAR T cell, you still could be treated with a bispecific such as talquetamab. In July 2012, Genmab entered into a collaboration with Janssen Biotech, Inc. (Janssen) to create and develop bispecific antibodies using Genmab's DuoBody technology platform. Few side effects, though. Patients enrolled in MomumenTAL-1 were assigned to a dose level and either the subcutaneous (n = 24; 31.6%) or intravenous (IV) dosing cohort (n = 52; 68.4%). 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The recently announced Phase 1/2 talquetamab trial data covered several hundred multiple myeloma patients, spanning two different doses and either weekly or fortnightly dosing schedules. Clipboard, Search History, and several other advanced features are temporarily unavailable. Other most common side effects are reported in table. About three-quarters of patients experienced cytokine-release syndrome, 60% experienced skin-related side effects such as rash, about half reported taste changes, and about half reported nail disorders. They can have a limited impact on quality of life measures.. One of these was the MonumenTAL-1 trial, which is a clinical trial for a newer bi-specific antibody called talquetamab, in patients with relapsed/refractory multiple myeloma. 2021 Aug 21;398(10301):665-674. doi: 10.1016/S0140-6736(21)01338-6. Usmani SZ, Garfall AL, van de Donk NWCJ, Nahi H, San-Miguel JF, Oriol A, Rosinol L, Chari A, Bhutani M, Karlin L, Benboubker L, Pei L, Verona R, Girgis S, Stephenson T, Elsayed Y, Infante J, Goldberg JD, Banerjee A, Mateos MV, Krishnan A. Lancet. In addition to various side effects including Cytokine Release Syndrome (SRS) which are seen in many targeted therapies, Talquetamab causes some skin related and nail disorder adverse eventsin 75% of patientsAll of the noted side effects, however, were considered manageable and reversible. An off-the-shelf immunotherapy for myeloma called talquetamab is The new exclusion criteria could represent an incremental headwind for Bluebird should it get to market, wrote SVB Securities analyst Mani Foroohar. Cytokine release syndrome, skin-related events, and dysgeusia were common with talquetamab treatment but were primarily low-grade. Lindsay Diamond Discusses Ongoing Role of Immunotherapy in Bladder Cancer. ASH 2021: Update on Talquetamab (Plain English Version), Soporte Para Pacientes de Mieloma Mltiple, University of Miami's Minimal Residual Disease (MRD) Meeting, Sequencing BCMA Therapies with Dr. Joshua Richter, Treating Multiple Myeloma by Exploding Cancerous Cells, Defining Your Risk of Progression With Smoldering Myeloma, Cevostamab, a New Bispecific Antibody for Refractory/Relapsed Multiple Myeloma, Blood-Based Single Cell Sequencing Holds the Key to Better Treatment Outcomes, Clinical Trial: Patient and Care Partner Experiences Living with Multiple Myeloma, HealthTree Coach has a New & Improved Website. MonumenTAL-1 trial Shows Promise With Talquetamab in R/R Myeloma Generic Name. Earlier in 2022, based on preliminary positive trial data, the FDA granted talquetamab Breakthrough Therapy designation. Bluebird got a much-needed lift this year when U.S. regulators approved two of its gene therapies. Antibody Treatment Makes Inroads Against Multiple Myeloma Cancers (Basel). Ash 2022 preview - a new multiple myeloma mechanism makes a splash In the phase 2 trial, doctors administered all the treatments subcutaneously using doses that had been safe and successful in the phase 1 trial. . But of course nothing works forever. As their number increases, the number of red blood cells, white blood cells and platelets, which are made from the same type of stem cell, decreases. Almost through cycle 8 of talquetamab / daratumumab / pomalidomide The drug produced a substantial response, with only low-grade side effects, in 70% of the patients. technology has been in development for decades, Rewired genetic 'clock' slows aging and increases cellular lifespan, Surfcycle: A highway-speed, lane-splitting stand-up scooter on steroids, Astronomers spot nearest star-destroying black hole. Epub 2023 Feb 3. FDA Approval Sought for Talquetamab for the Treatment of R/R Multiple At the two recommended subcutaneous doses for a phase . Emerging Strategies to Manage Relapsed and/or Refractory Multiple Myeloma.
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